Evolence® (Collagen-based wrinkle filler)

Recently, the FDA approved the use of Evolence, a new collagen-based dermal filler, for the correction of facial wrinkles and folds, such as nasolabial folds. While new to the United States, Evolence has been available in other markets such as Canada, Europe and Israel for several years.

The filler uses natural porcine (pig) collagen to replace the body's lost collagen and add volume in depleted areas for a more youthful appearance. This new generation collagen filler is intended for injection into the mid-to-deep dermis for the correction of moderate to deep facial wrinkles and folds, such as nasolabial folds. Results are said to be visible at the time of treatment.

The most common side effects are usually injection-site related and include mild swelling, redness, and pain. Other rare side effects include the development of small areas of firmness under the skin at the treated sites that may be noticed when the areas are pressed upon. A skin test is not required because porcine collagen is the most genetically similar to human collagen.

Evolence is clinically proven to last for six months. Additional data for 12-month duration approval is being filed with the FDA.

Additional Information:

Fagien, Steven, Klein, Arnold W. A Brief Overview and History of Temporary Fillers: Evolution, Advantages, and Limitations. Plast. Reconstr. Surg. 120(6S): 8S-16S, 2007.